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November 7, 2006

The science behind the scene


Science and technology are not all about action.
It's what goes on behind the scene that makes a difference

Story by ORATIP NIMKANNON

At the National Science and Technology Fair last August, a line up of robots _ a receptionist bot, a rescue personnel bot, a babysitter bot, and a therapeutic baby seal bot _ was the highlight of the show.

In a way, these robots provide a good example of science and technology in action. The robots are real, touchable, moveable, and fascinating, and they represent cutting-edge technologies that most people can appreciate. More importantly, they are the products of years of research that present technology in ways that people can easily understand.

Action, however, is not always what science and technology is all about. Like robots, most of what we see in today's market _ home appliances, sports equipment, electronic appliances, automobiles, and more _ are products of years of research and countless trials and errors.

``Being a researcher means to study one topic until we know all there is to know about something,'' says Assist Prof Dr Apinpus Rujiwatra of Chiang Mai University. ``But of course, we can never reach that point.'' As one of the recipients of the 2006 Young Scientist Awards, Dr Apinpus, traveled to Bangkok to give a special lecture on her research for the thirty-second Congress on Science and Technology of Thailand. Research, she says, takes up 50 percent of her time at the university, while the remainder is spent on teaching.

``I work on my research until 9 or 10pm everyday, seven days a week,'' she says. ``I almost have no time to travel anywhere.'' Determination and dedication to the work is what it takes to overcome all the hurdles. ``The lack of financial funding is not as important as the lack of research personnel and student helpers. This is particularly true in universities that are located in rural provinces.'' The 2006 Young Scientists

This year, a total of five scientists receive the Young Scientist Award from the Foundation for the Promotion of Science and Technology (FPST). Joining Dr Apinpus are Assist Prof Dr Joongjai Panpranot (Chulalongkorn University), Assist Prof Dr Puangratana Pairor (Suranaree University of Technology), Dr Visith Thongboonkerd (Mahidol University), and Dr Shanop Shuangshoti (Chulalongkorn University).

Since 1991, the foundation has handed the award to nearly 60 Young Scientists. The award is reserved specifically for researchers 35 years old and under with an outstanding research work in basic science, namely physics, chemistry, biology, mathematics, or related fields. Besides being published in at least three standard scientific journals, the work must also be cited in articles written by a number of other scientists, and finally, the work must have a high impact factor.

Although this year's five winning researchers did not create breakthroughs in science or technology, they successfully built upon pre-existing work that is geared toward serving local needs. Often, this means that the works are still in the laboratory stages, where the techniques and processes of perfection are being pursued.

Enhancing the fundamentals

Dr Apinpus' award wining research not only promises to increase the number of material choices for future technological applications, but also to improve the efficiency of future electronic appliances. In short, her research on the synthesis and characterisation of lead titanate (PT) via solvothermal synthesis involves the development of a technique to be used in the production of piezoelectric powders. Lead titanate is a ceramic perovskite material that develops a voltage difference across two of its faces when compressed. One application of these powders, she says, is in the production of electronic sensors and microchips.

``We can then apply this technique to the exploration of other powders with various electromagnetic properties. This will allow us to, one day, produce our own powders, instead of importing them from overseas like we do today,'' she adds.

To some extent, the industrial sector usually benefits one way or another from scientific research conducted in universities. Dr Joongjai Panpranot, a researcher and lecturer at Chulalongkorn University's Department of Chemical Engineering, says that she has received a specific assignment from the industry to research the effect of selected metal catalysts on the process of acetylene hydrogenation. This process removes such impurities as acetylene from the production of polyethylene, and is widely used in the petrochemical industry, particularly in the production of plastic.

``Normally, when we extract natural gases, we get several byproducts, like methane and ethane,'' she says. ``Ethylene is what we use to produce polyethylene, which is the most common compound used to make plastic. But the ethylene we get is not always 100 percent pure. There will always be impurities like acetylene that must be removed.'' Dr Joongjai's research, as a result, focuses on exploring the catalytic properties of palladium over titanium dioxide (Pd/Tio2) catalyst in the process of removing acetylene impurities. ``This purification of ethylene is the very first process in the production line,'' she says. The end result of a purer ethylene is a better polymer quality. ``One objective of this research is to discover a more effective catalyst than those currently sold on the market,'' she adds.

Diversity of disciplines

On a slightly different note, Dr Puangratana Pairor's research focuses on the understanding of metal-superconductor junctions through a technique called tunneling spectroscopy. The majority of her work involves data extractions and simulations in a computer, which helps her to obtain clues about the mechanism of superconductivity.

A superconductor, Dr Puangratana explains, is a result of a change of state of a metal, after it is cooled below a critical temperature of -150 degrees Celsius or lower. At this temperature, a superconductor ``conducts electric current without resistance and expels magnetic fields completely,'' Dr Puangratana says.

This remarkable property of superconductors, she adds, makes possible many technological applications. ``Among them is the magnetic-levitation (maglev) train, which is a transport vehicle designed to float above the train rails on powerful magnets, virtually eliminating friction between the train and its tracks,'' she elaborates. Because Maglev trains make no physical contact with the track, they could potentially reach velocities comparable to turboprop and jet aircraft (500 to 580 km/h), making them the fastest trains available.

Research is also a critical part of the study of medicine. As a nephrologist, Dr Visith Thongboonkerd has a particular interest in applying a technique called ``proteomics'' to the study of kidney diseases. ``In general, proteomic technologies make feasible a simultaneous analysis of a large number of proteins, which can also be applied to other sectors, such as agriculture, animal breeding, and farming,'' he says.

``This technique speeds up the study of proteins and allows us to see a broader and better picture of organisms, cells, or organs. Whereas in the past, we had to study one area at a time, and then try to connect the dots,'' he adds.

The progress of his research translates into a better understanding of normal physiology and pathogeny - the development of a disease or disorder, mainly as observed at the biochemical or cellular level - while improving therapeutic outcome, as in reducing disease complications and shortening the duration of hospitalisation. Other goals include the developments of new vaccines and the discovery of biomarkers, which make possible early diagnosis and identification of diseases.

``All these are ultimate goals,'' says Dr Visith. ``We must first apply the proteomic technologies to study details of various diseases, before we can realise these goals.''

Although it may take years before they arrive at any major scientific break-throughs, this year's young scientists all agree that the work must continue. In a way, this endless search for knowledge is the beauty of the research itself. ``I find so much joy in every step of the progress I've made,'' says Dr Puangratana. ``It gives me a sense of pride and encourages me to continue working. I think that's what attracts me to research,'' she adds.

The thirty-second Congress on Science and Technology of Thailand, October 10-12, was organised by the Science Society of Thailand, under the patronage of HM the King, in association with Chulalongkorn University's Faculty of Science. For more information, visit www.stt32.scisoc.or.th .

PROFILES: Meet the Young Scientists of 2006

Assist Prof Dr Apinpus Rujiwatra completed her Bachelor of Science in Chemistry, with first class honours, from Chiang Mai University in 1995, before leaving for Japan under the Monbusho scholarship programme to undertake a two-year research project at Saitama University.

She returned to Thailand in 1997 and became a full-time lecturer at Chiang Mai University's Faculty of Science. Four years later, Dr Apinpus left to complete her doctorate degree at Oxford University, where she initiated research on the synthesis and characterisation of novel framework compounds using soft chemical techniques under the supervision of Prof Mathew Rosseinsky.

In 2001, Dr Apinpus completed her PhD and returned to her post at Chiang Mai University, where she continued the research based on the application of soft chemical techniques and crystallography.

``I have always enjoyed doing research. It's exciting and fun, just that simple,'' she says, ``but a more importantly, research is a tool for human resources development.

``Undergraduate students on my research team have demonstrated an extremely high potential to absorb information, think critically, and deliver the work. The detailed processes of research inspire them to learn more. I'm confident these students will continue to explore the secrets of science, as well as pass on the knowledge to the next generation,'' Dr Apinpus adds.

Assist Prof Dr Joongjai Panpranot graduated with a Bachelor of Science in chemical engineering from Chulalongkorn University's Faculty of Science in 1995. In 1996, she received a scholarship from the Ministry of Science and Technology to study at the master and doctorate levels in the United States. Six years later, Dr Joongjai graduated from West Virginia University and Clemson University with a MS and PhD in Chemical Engineering.

Dr Joongjai joined the Department of Chemical Engineering at Chulalongkorn University in 2002, where she became a member of the Centre of Excellence in Catalysis and Catalytic Reaction Engineering. Her primary research involves mainly the study of physiochemical property and catalytic performance of transition metal catalysts for catalyst design and selection in petrochemical industry.

Doing research, she says, involves an intense inspiration. ``Even though the industry may have no practical use for my research results at this point, at least it helps us to understand the nature of these catalysts and the impact of their chemical properties on the production line.

``It's not just doing it to get a result for publication in a journal. To me, that's useless,'' she adds.

Assist Prof Dr Puangratana Pairor obtained a Bachelor of Science in physics from Chulalongkorn University in 1994 with first class honours. Soon after, she received a scholarship from the Development and Promotion of Science and Technology Talents (DPST) to study at the master and doctorate levels at the University of Toronto, Canada.

In 1996, Dr Puangratana completed her Masters of Science in physics and commenced her study of metal-superconductor tunneling spectroscopy, which is one of the most powerful tools used to study physical properties of a superconductor.

Five years later, she obtained a PhD in Physics and joined Suranaree University of Technology's Department of Physics, where she continued her research on tunneling spectroscopy of a metal-superconductor junction and also taught students at both the undergraduate and graduate levels.' The results of Dr Puangratana's research studies provide important information needed to correctly interpret the metal-superconductor tunneling data.

Her research in 2003 and 2004 earned her the 2004 Outstanding New Researcher Award from the Thailand Research Fund (TRF).

Assoc Prof Dr Shanop Shuangshoti graduated with a Doctor of Medicine (MD) from Prince of Songkla University's Faculty of Medicine in 1995, before beginning his residency training in Anatomic Pathology at the Department of Pathology, Faculty of Medicine, Chulalongkorn University.

In 1998, he became a Diplomate of the Thai Board of Anatomic Pathology and also became a visiting pathologist at the Department of Neuropathology, Royal Perth Hospital, Australia in 1999.

A year later, Dr Shanop flew to the United States to join the National Institute of Mental Health's Clinical Brain Disorders Branch as a fellow neuropathologist. In 2002, Dr Shanop was included as one of the contributors of the World Health Organisation (WHO) Classification of Tumours of the Nervous System, which is one of the tumour classification series currently used worldwide.

He returned to Thailand in 2001 and served as a neuropathologist at Chulalongkorn Hospital. His major research interest has been the morphological aspects of tumours, particularly those of the nervous system, and how to improve pathological diagnoses.

So far, Dr Shanop has published 56 articles, 50 of which have been published in international journals.

Dr Visith Thongboonkerd obtained a Doctor of Medicine (MD) with first class honours from Chiang Mai University's Faculty of Medicine. From 1994 to 1998, he was selected for further training in Internal Medicine and Nephrology from 1998 to 2000. He received diplomas in both specialties.

Dr Visith's interest in research began during his training at the Department of Medicine, Maharaj Nakorn Chiang Mai Hospital. To address the question of how to manage and prevent kidney diseases more effectively, he went to the University of Louisville, in the American state of Kentucky for further training. There, he undertook research on projects that utilised proteomics _ a novel technology that involves the large-scale study of the structures and functions protein _ to study proteins in urine and kidney tissues.

In 2004, Dr Visith joined Mahidol University's Faculty of Medicine at Siriraj Hospital. He now serves as a supervisor for the Medical Scholars Programme, a training programme for MS and PhDs in Immunology. To him, advances in medical research can create an impact on communities in a unique way. ``If I continue in that same direction, the impact is not so great. Whereas my research, particularly proteomics, creates a much greater impact not only in terms of gaining deeper knowledge about the technology itself, but also in terms of a much more comprehensive understanding of diseases,'' he adds.

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Last modified: November 6, 2006