The first gene ever to resist Effavirenz, a type of drug used in the treatment of human immunodeficiency virus (HIV) type 1, has been discovered by researchers from Mahidol University's Faculty of Medicine at Ramathibodi Hospital, reports said on Monday.
"This is the first discovery [of gene CYP2B6]. The researchers have already applied for patent registration. The study shows the relationship of the gene with the level of Effavirenz concentration. Patients with high Effavirenz concentration in their blood suffer from neural toxicity," said Dr Chonlapat Sukasem, the hospital's head of the Division of Pharmacogenomics.
The situation can cause nightmares, depression and other effects. It can even drive patients to commit suicide, he added.
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