Barcelona, Real Madrid and Malaga will look to set themselves up for a place in the Champions League semi-finals with impressive performances in their quarter-final first legs this week.
Barcelona's Lionel Messi (L) celebrates with Cristian Tello and Andres Iniesta (R) during a Spanish league match on March 30, 2013. Barcelona travel to Paris Saint-Germain, whose limited defensive style of play may appeal to the offensive-minded Catalan outfit.
The last time the Spanish had three sides in the last four was in the 1999/2000 season.
Barcelona travel to Paris Saint-Germain, whose limited defensive style of play may appeal to the offensive-minded Catalan outfit.
With both Real and Malaga hosting the first legs against Galatasaray and Borussia Dortmund respectively they will want to take solid leads to Turkey and Germany the following week.
The other quarter-final sees runaway German league leaders Bayern Munich host Serie A pacesetters Juventus, who will be hoping Bayern left their best form behind them with the 9-2 mauling of Hamburg on Saturday.
Barcelona will be boosted by the return of ailing coach Tito Vilanova to the dugout for the first time since undergoing two months of treatment for cancer in New York.
They will also make the trip to Paris with full-back Jordi Alba and playmaker Xavi Hernandez, although there are doubts over the fitness of both with Alba having missed Spain's midweek 1-0 2014 World Cup qualifier win over France.
However, they are reported to have recovered from their respective hamstring problems and leaves Barcelona only without injured defensive duo Carles Puyol and Adriano.
Spain's scorer last week, Pedro Rodriguez, is suspended.
PSG have plenty to be encouraged about as they are unbeaten at home in European competition for over six years while Barcelona have already lost twice on their travels in this season's tournament.
They also welcome back leading striker Zlatan Ibrahimovic, who had his two-match Champions League suspension reduced last week, and he will be looking to deny one of his former sides a place in the last four.
PSG coach Carlo Ancelotti, a winner of the competition both as a player and as a manager, said that he would not be changing anything in their strategy as they bid to emulate their 1995 predecessors' achievement in eliminating Barcelona in the quarter-finals.
"Everyone knows all about Barca," said the 53-year-old Italian.
"But we want to put out a side that is looking to play football, even if we are up against one of the best sides in the world."
Real coach Jose Mourinho, who is bidding to win the trophy for the third time with a different side, having won with Porto in 2004 and Inter Milan in 2010, had been reported to have advised Ancelotti on how to beat his bitter domestic rivals, though, the Italian denied such help had been forthcoming.
Mourinho has enough of a challenge in keeping his job than helping others do so after a disappointing title defence in Spain and only a Champions League win might suffice to see him at the Bernabeu next term.
"It will be tough, but we must try and get a positive result at home in the first leg, which is not what we managed to do against Manchester United (a 1-1 draw in Madrid)," he said.
"We must go there with at least a small advantage."
While Mourinho revels in his nickname of 'The Special One' his Galatasaray counterpart, Fatih Terim, is known as 'The Emperor' after three spells in charge.
Having guided them to their first Champions League quarter-final since 2001 he is looking forward to taking them further.
"We don't need to describe Real Madrid, everyone knows they are a very good team, known across the world, and they eliminated Manchester United," he told the Guardian.
"But we are also a good team, with good players. We respect them, but we have confidence for the game."
Malaga's impressive run in the competition has come despite worrying times behind the scenes with UEFA banning them from their next European competition because of debts.
"The sale of Nacho Monreal (to Arsenal in the transfer window) was taken badly in the dressing room," said Argentinian central defender Martin Demichelis.
"Instead of thinking of improving the team with new players, the owners have only thought of selling those that are the most marketable."