Jab mix studied

Jab mix studied

Queueing up for Covid-19 inoculation at a mobile vaccination unit at Bang Khen School in Bangkok's Laksi district on Tuesday. (Photo: Pattarapong Chatpattarasill)
Queueing up for Covid-19 inoculation at a mobile vaccination unit at Bang Khen School in Bangkok's Laksi district on Tuesday. (Photo: Pattarapong Chatpattarasill)

A team at Chulalongkorn University is studying whether a combination of vaccines can increase Covid immunity.

Researchers at the university’s Centre of Excellence in Clinical Virology are looking into whether Covid-19 shots from different vaccine makers can better boost immunity and maximise safeguards against infection from the rapidly spreading Delta (Indian) variant.

Study results are expected in a few months, according to the head of the centre, Dr Yong Poovorawan.

His research team is working with partners to study administering the vaccine using a combination of Sinovac and AstraZeneca.

The study might show that combining vaccines could lift immunity and guard against infections more effectively than relying on a single brand.

According to Dr Yong, the study involves using Sinovac vaccine as the first dose, followed by the AstraZeneca vaccine as a second dose administered four weeks later.

"In laboratory tests, we have seen very satisfying results. But we are still very concerned about side-effects," he said.

The results of the study will be forwarded to the government, he added.

Dr Yong also stressed the need to slow rapid transmission of the Delta strain of the virus. He said some people have shown low immunity after receiving two shots of either Sinovac or AstraZeneca and that they could benefit from a third shot which, if administered at a proper time, might spur immunity tenfold.

Dr Yong insisted it would be unnecessary for people to go for a test to gauge their levels of immunity after receiving vaccine shots. Moreover, different hospitals employ different methods to run such tests and this could put accuracy in doubt.

On combining vaccines, the professor said the practice is done in many European countries. However, he noted that Thailand is different because the vaccines made available locally are either inactivated or viral vector types. Combining them may not be as easy as in Europe.


  • accuracy: the state of being exact or correct; the ability to do something skilfully without making mistakes - ความแม่นยำ
  • boost: to increase; to strengthen - เพิ่ม; ทำให้มีกำลังมากขึ้น
  • combination (noun): the mixture you get when two or more things are combined - การรวมกัน
  • dose (noun): an amount of drug or something else that you take at a single time or affects you at a single time - ปริมาณที่ให้ต่อครั้ง
  • forward: to send onwards - ส่งต่อ
  • maximise: to increase something as much as possible - ทำให้มีสูงสุด
  • safeguard: something which protects something/somebody from loss, harm or damage; something which keeps something/somebody safe - สิ่งป้องกัน, สิ่งคุ้มกัน
  • side-effect: an effect of a medicine that is not intended and could be unpleasant - ผลข้างเคียง
  • spur: to cause something to happen - ก่อให้เกิด 
  • vector (noun): in medicine and epidemiology, "any agent (person, animal or microorganism) that carries and transmits an infectious pathogen into another living organism" (Source: Wikipedia) - ตัวนำโรค
  • virology (noun): the scientific study of viruses and the diseases caused by them - ไวรัสวิทยา, การศึกษาเกี่ยวกับไวรัสและโรคที่เกิดจากไวรัส
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